Methylenetetrahydrofolate reductase: A common human polymorphism and its biochemical implications
نویسندگان
چکیده
منابع مشابه
Impact of Methylenetetrahydrofolate Reductase C677T Polymorphism on the Risk of Gastric Cancer and Its Interaction with Helicobacter pylori Infection
Background: Attempts for early detection of gastric cancer have recently focused on host's genetic susceptibility factors and gene-environment interactions. We have, herein, studied the association of MTHFR C677T single nucleotide polymorphism (SNP) and its interaction with Helicobacter pylori infection, smoking, age and gender on the risk of gastric cancer among an Iranian population. Methods:...
متن کاملMethylenetetrahydrofolate reductase polymorphism and pre-eclampsia.
A common missense mutation in the methylenetetrahydrofolate reductase (MTHFR) gene, a C to T substitution at nucleotide 677, is responsible for reduced MTHFR activity and associated with modestly increased plasma homocysteine concentrations. Since underlying maternal vascular disease increases the risk of pre-eclampsia, we had the working hypothesis that pre-eclampsia patients would have an inc...
متن کاملEvaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...
متن کاملA methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
We examined the relationship of a common polymorphism (667C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene with the risk of colorectal cancer in a case-control study conducted in the Health Professionals Follow-up Study. MTHFR genotypes were ascertained from blood samples among 144 men previously diagnosed with colorectal cancer and 627 controls. The adjusted odds ratio (OR) for t...
متن کاملAssociation between the A1298C Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...
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ژورنال
عنوان ژورنال: The Chemical Record
سال: 2002
ISSN: 1527-8999,1528-0691
DOI: 10.1002/tcr.10006